Lipid Biotechnology, Chemistry, and Phytochemicals Laboratory Website

Description of Research Interests

Food Chemistry: Lipid biotechnology/chemistry/biochemistry. We work on the chemical and enzymatic modification of lipids, including the production of structured lipids and various fat analogs. We then study chemical, physical and physiological properties of modified lipids and their food applications.  We design fat analogs for use in infant formula, trans-free margarines, trans-free spreads, trans-free shortenings, cosmetics, nutraceuticals, or as food ingredients.  We also isolate, characterize, and assess the antioxidant capacities of phytochemicals.

Courses Taught

FDST 6500/8500: Graduate Seminars
FDST 8010: Food Lipids
FDST 8100: Food Carbohydrates

Selected Recent Publications

Kadamne, J.T., Ifeduba, E.A., Akoh, C.C. and Martini, S. 2017. Sonocrystallization of interesterified fats with 20 and 30% C16:0 at sn-2 position. J. Am. Oil Chem. Soc. 94:3-18.

Jin, G., Kim, J., Lee, Y., Akoh, C.C., Chun, H.S., Ahn, S. and Kim, B.H. 2017. A nuclear magnetic resonance spectroscopy approach to discriminate the geographic origin of roasted Asian sesame oils. J. Oleo Sci. 66:337-344.

Moore, M.A. and Akoh, C.C. 2017. Enzymatic interesterification of coconut and high oleic sunflower oils for edible film application. J. Am. Oil Chem. Soc. 94:567-576.

Zhang, Y., Zhai, X., Gao, L., Jin, J., Zhong, Q., Sun, C., Yan, L., Liu, R., Akoh, C.C., Jin, Q. and Wang, X. 2017. Quality of wood-pressed rapeseed oil. J. Am. Oil Chem. Soc. 94:767-777.

Şahin Yeşilçubuk, N. and Akoh, C.C. 2017. Biotechnological and novel approaches for designing structured lipids intended for infant nutrition. J. Am. Oil Chem. Soc. (Invited review). J. Am. Oil Chem. Soc. 94:1005-1034.

Kadamne, J.T., Ifeduba, E.A., Akoh, C.C. and Martini, S. 2017. Sonocrystallization of interesterified fats with 20 and 30% of stearic acid at sn-2 position and their physical blends. J. Am. Oil Chem. Soc. 94:1045-1062.

Pastrana-Bonilla, E., Akoh, C.C. and Cerquera, N.E. 2017. Identification and quantification of anthocyanins in muscadine grapes by HPLC and HPLC-MS. ARPN J. Eng. Appl. Sci. 12:626-631.

Nielsen, P.M. and Akoh, C.C. 2017. Biodiesel from low-quality feed stocks. Inform. 28(10): 23-27. doi.10.21748/inform.10.2017.23.

Liang, P., Li, R., Sun, H., Zhang, M., Cheng, W., Chen, L., Cheng, X. and Akoh, C.C. 2017. Phospholipids composition and molecular species of large yellow croaker (Pseudosciaena crocea) roe. Food Chem. (in press).

Akoh, C.C. 2017.  Food Lipids: Chemistry, Nutrition, and Biotechnology. Fourth Edition, Revised and Expanded. CRC Press/Taylor & Francis Group, Boca Raton, FL, 1047 pages.

Sahin-Yesilcubuk, N. and Akoh, C.C. 2017. Encapsulation Technologies for Lipids. In “Food Lipids: Chemistry, Nutrition, and Biotechnology.” (Akoh, ed.), Fourth Edition, Revised and Expanded. CRC Press/Taylor & Francis Group, Boca Raton, FL, p. 453-476.

Lai, O.M., Phuah, E.T., Lee, Y.Y., Akoh, C.C., and Weete, J.D. 2017. Microbial Lipases. In “Food Lipids: Chemistry, Nutrition, and Biotechnology.” (Akoh, ed.), Fourth Edition, Revised and Expanded. CRC Press/Taylor & Francis Group, Boca Raton, FL, p. 853-898.

Akoh, C.C. and Kim, B.H. 2017. Structured Lipids. In “Food Lipids: Chemistry, Nutrition, and Biotechnology.” (Akoh, ed.), Fourth Edition, Revised and Expanded. CRC Press/Taylor & Francis Group, Boca Raton, FL, p. 941-972.

Pande, G. and Akoh, C.C. 2016. Pomegranate Cultivars (Punica granatum L.). In ‘Nutritional Composition of Fruit Cultivars.” (Preedy and Simmonds, eds.), Academic Press, p.667-689.

Zou, L., Pande, G. and Akoh, C.C. 2016. Infant formula fat analogs and human milk fat: new focus on infant developmental needs. Ann. Rev. Food Sci. Technol. (invited review), 7:139-165.

Sproston, M.J. and Akoh, C.C. 2016. Enzymatic modification of anhydrous milkfat with n-3 and 6 fatty acids for potential use in infant formula: comparison of methods. J. Am. Oil Chem. Soc. 93:251-265.

Ifeduba, E.A., Martini, S. and Akoh, C.C. 2016. Enzymatic interesterification of high oleic sunflower oil and tripalmitin or tristearin. J. Am. Oil Chem. Soc. 93:61-67.

Li, G., Wu, S., Wang, L. and Akoh, C.C. 2016. Concentration, dietary exposure and health risk estimation of polycyclic aromatic hydrocarbons (PAHs) in youtiao, a Chinese traditional fried food. Food Control 59:328-336.

Ifeduba, E.A. and Akoh, C.C. 2016. Microencapsulation of stearidonic acid soybean oil in Maillard reaction-modified complex coacervates. Food Chem. 199:524-532.

Pande, G. and Akoh, C.C. 2016. Enzymatic synthesis of tyrosol-based phenolipids: characterization and antioxidant activities. J. Am. Oil Chem. Soc. 93:329-337.

Álvarez, C.A. and Akoh, C.C. 2016.  Enzymatic production of high sn-2 DHA and ARA modified oils for the formulation of infant formula fat analogs. J. Am. Oil Chem. Soc. 93:383-395.

Álvarez, C.A. and Akoh, C.C. 2016. Preparation of infant formula fat analog containing capric acid and enriched with DHA and ARA at the sn-2 position. J. Am. Oil Chem. Soc. 93:531-542.

Jiang, X, Wu, S., Zhou, Z. and Akoh, C.C. 2016. Physicochemical properties and volatile profiles of cold-pressed Trichosanthes kirilowii Maxim seed oils. Int. J. Food Prop. 19:1765-1775.

Sproston, M.J., Ifeduba, E.A. and Akoh, C.C. 2016. Structured lipids for food and nutraceutical applications. AOCS Lipid Library (invited review). August 30, pages 1-7. http://dx.doi.org/10.21748/lipidlibrary.41522

Sproston, M.J. and Akoh, C.C. 2016. Antioxidative effects of a glucose-cysteine Maillard reaction product on the oxidative stability of a structured lipid in a complex food emulsion. J. Food Sci. 81:C2923-C2931.

Zou, L. and Akoh, C.C. 2015. Antioxidant activities of annatto and palm tocotrienol-rich fractions in fish oil and structured lipid-based infant formula emulsion. Food Chem. 168:504-511.

Zou, L. and Akoh, C.C. 2015. Oxidative stability of structured lipid-based infant formula emulsion: effect of antioxidants. Food Chem. 178:1-9.

Kim, B.H. and Akoh, C.C. 2015. Recent research trends on the enzymatic synthesis of structured lipids. J. Food Sci. 80:C1713-C1724.

Ifeduba, E.A. and Akoh, C.C. 2015. Microencapsulation of stearidonic acid soybean oil in complex coacervates modified for enhanced stability. Food Hydrocolloids 51:136-145.

Álvarez, C.A. and Akoh, C.C. 2015. Enzymatic synthesis of infant formula fat analog enriched with capric acid. J. Am. Oil Chem. Soc. 92:1003-1014.

Li, R., Sabir, J.S.M., Baeshen, N.A. and Akoh, C.C. 2015. Enzymatic synthesis of refined olive oil-based structured lipids containing omega-3 and -6 fatty acids for potential application in infant formula J. Food Sci. 80: H2578-2584.

Kim, S., Kim, I.-H., Akoh, C.C. and Kim, B.H. 2014. Enzymatic production of cocoa butter equivalents high in 1-palmitoyl-2-oleoyl-3-stearin in continuous packed bed reactors. J. Am. Oil Chem. Soc. 91:747-757.

Ifeduba, E.A. and Akoh, C.C. 2014. Modification of stearidonic acid soybean oil by immobilized Rhizomucor miehei lipase to incorporate caprylic acid. J. Am. Oil Chem. Soc. 91:953-965.

Akoh, C.C. 2014. Professional pathways. Inform 24:384-386. 

Wu, S., Xu, T. and Akoh, C.C. 2014. Effect of roasting on the volatile constituents of Trichosanthes kirilowii seeds. J. Food Drug Anal. 22:310-317.

Li, R., Pande, G., Sabir, J.S.M., Baeshen, N.A. and Akoh, C.C. 2014. Enrichment of refined olive oil with palmitic and docosahexaenoic acids to produce human milk fat analogue. J. Am. Oil Chem. Soc. 91:1377-1385.

El-Domyati, F.M., Abdel Aziez, A.Z., Atef, A., Elhalwagi, A., Sabir, J.S.M., Ramadan, A.M., Gadalla, N.O., Edris, S., Baeshen, M.N., Hajrah, N.H., Al-Kordy, M.A., Al-Hajar, A.S.M.,  Akoh, C.C., and Bahieldin. 2014. Functional genomic analysis for  overproduction of key terpenoid indole alkaloids in mature leaf of Catharanthus roseus. Life Sci. J.11:1213-1220.

Kleiner, L. and Akoh, C.C. 2014. Lípidos estructurados en leches infantilespara una mejor salud y nutrición. (Structured lipids in infant formula for better nutrition and health). Aceites y Grasas  3:462-468.

Li, H., Akoh, C.C., Li, J., Rao, H., and Deng, Z. 2014. trans Fatty Acids. In “Food Safety Chemistry: Toxicant Occurrence, Analysis and Mitigation.” (Yu, Wang, and Sun, eds.),  CRC Press/Taylor & Francis Group, Boca Raton, FL, p. 133-155.

Pande, G., Nagachinta, S., and Akoh, C. C. 2014. An Overview of the Composition of Bottle Feeds. In “Handbook of Dietary and Nutritional Aspects of Bottle Feeding.” (Preedy, Watson, and Zibadi, eds.), Wageningen Academic Publishers: Wageningen, The Netherlands p. 191-208.

Pande, G., Sabir, J.S.M., Baeshen, N.A. and Akoh, C.C. 2013. Enzymatic synthesis of extra virgin olive oil based infant formula fat analogues containing ARA and DHA: one-stage and two-stage syntheses. J. Agric. Food Chem. 61:10590-10598.

Pande, G. and Akoh, C.C. 2013. Enzymatic synthesis of trans-free structured margarine fat analogues with high stearate soybean oil and palm stearin and their characterization LWT-Food Sci. Technol. 50:232-239.

Turan, D., Yesilcubuk, N.S., and Akoh, C.C. 2013. Enrichment of sn-2 position of hazelnut oil with palmitic acid: optimization by response surface methodology. LWT-Food Sci. Technol. 50:766-772.

Pande, G., Akoh, C. C., and Shewfelt, R. L. 2013. Utilization of enzymatically interesterified cottonseed oil and palm strearin-based structured lipid in the production of trans-free margarine. Biocat. Agric. Biotechnol. 2:76-84.

Jeon, H, Kim, I.H., Lee, C., Choi, H.D., Kim, B.H., and Akoh, C.C. 2013. Discrimination of origin of sesame oils using fatty acid and lignin profiles in combination with canonical discriminant analysis. J. Am. Oil Chem. Soc. 90:337-347.

Ifeduba, E.A., Awachie, M.N., Sabir, J.S.M., and Akoh, C.C. 2013. Fatty acid composition of Irvingia gabonensis and Treculia africana seed lipids and phospholipids. J. Am. Oil Chem. Soc. 90:517-528.

Nagachinta, S. and Akoh, C.C. 2013. Production and characterization of DHA and GLA-enriched structured lipid from palm olein for infant formula use. J. Am. Oil Chem. Soc. 90:1141-1149.

Zou, L. and Akoh, C.C. 2013. Identification of tocopherols and tocotrienols, and their fatty acid esters in residues and distillates of structured lipids purified by short path distillation. J. Agric. Food Chem. 61:238-246.

Pande, G. and Akoh, C.C. 2013. Enzymatic modification of lipids for trans-free margarine. Lipid Technol. 25:31-33.

Zou, L. and Akoh, C.C. 2013. Characterisation and optimisation of physical and oxidative stability of structured lipid-based infant formula emulsion: effects of emulsifiers and biopolymer thickeners. Food Chem. 141:2486-2494.

Ifeduba, E.A. and Akoh, C.C. 2013. Chemoenzymatic method for producing stearidonic acid concentrates from stearidonic acid soybean oil. J. Am. Oil Chem. Soc. 90:1011-1022.

Liu, M., Yang, F., Shi, H., Akoh, C.C. and Yu, L. 2013. Preparative separation of triterpene alcohol ferulates from rice bran oil using high performance counter-current chromatography. Food Chem. 139:919-924.

Zhou, Q., Shi, H., Liu, J., Zhang, X., Gao, B., Lu, W., Akoh, C.C. and Yu, L. 2013. Identification and quantification of phytochemical composition, anti-inflammatory, cellular antioxidant and radical scavenging activities of twelve Plantago species. J. Agric. Food Chem. 61:6693-6702.

Nagachinta, S. and Akoh, C.C. 2013. Synthesis and incorporation of structured lipid enriched with omega fatty acids and sn-2 palmitic acid in powdered infant formula. J. Agric. Food Chem. 61:4455-4463.

Pande, G., Sabir, J.S.M., Baeshen, N.A. and Akoh, C.C. 2013. Synthesis of infant formula fat analogs enriched with DHA from extra virgin olive oil and tripalmitin. J. Am. Oil Chem. Soc. 90:1311-1318.

Nagachinta, S. and Akoh, C.C. 2013. Spray-dried structured lipid containing long-chain polyunsaturated fatty acids for use in infant formulas. J. Food Sci. 78:C15223-C1528.